科学家报道不同人类组织中端粒长度的决定因素 作者： 发布时间：/9/12 15:26:51 9月11日，美国芝加哥大学Brandon L. Pierce研究团队在《科学》杂志发表论文，报道不同人体组织中端粒长度的决定因素。
研究人员表征了来自6391个组织样本的端粒长度（TL）变异性，这些样本代表了来自基因型组织表达（GTEx）项目的20多个组织类型和952名个体。研究人员描述了不同组织类型之间的差异、组织类型之间的正相关以及与年龄和血统的关联。 研究人员表明，遗传变异影响多种组织类型中的TL，并且TL可能介导年龄对基因表达的影响。这些结果提供了有关健康组织中TL的基础了解，有助于解析TL和人类健康的流行病学研究。 据悉，端粒缩短是衰老的标志。血细胞中的TL已被广泛研究作为人类衰老和疾病的生物标记。但是，关于非血液的疾病相关组织类型中TL的变异性知之甚少。 附：英文原文 Title: Determinants of telomere length across human tissues
Author: Kathryn Demanelis, Farzana Jasmine, Lin S. Chen, Meytal Chernoff, Lin Tong, Dayana Delgado, Chenan Zhang, Justin Shinkle, Mekala Sabarinathan, Hannah Lin, Eduardo Ramirez, Meritxell Oliva, Sarah Kim-Hellmuth, Barbara E. Stranger, Tsung-Po Lai, Abraham Aviv, Kristin G. Ardlie, Franois Aguet, Habibul Ahsan, GTEx Consortium*, Jennifer A. Doherty, Muhammad G. Kibriya, Brandon L. Pierce
Issue Volume: /09/11
Abstract: Telomere shortening is a hallmark of aging. Telomere length (TL) in blood cells has been studied extensively as a biomarker of human aging and disease; however, little is known regarding variability in TL in nonblood, disease-relevant tissue types. Here, we characterize variability in TLs from 6391 tissue samples, representing 20 tissue types and 952 individuals from the Genotype-Tissue Expression (GTEx) project. We describe differences across tissue types, positive correlation among tissue types, and associations with age and ancestry. We show that genetic variation affects TL in multiple tissue types and that TL may mediate the effect of age on gene expression. Our results provide the foundational knowledge regarding TL in healthy tissues that is needed to interpret epidemiological studies of TL and human health.
DOI: 10.1126/science.aaz6876
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期刊信息 Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：41.037官方网址：投稿链接：
