先导化合物,lead compound
1)lead compound先导化合物
1.Design, synthesis and biological activity of the novellead compound ethyl 2-(2-chloro-4-trifluoromethylphenoxy)-4-trifluoromethyl-thiazole-5-carbonate;新型先导化合物2-(2-氯-4-三氟甲基苯氧基)-4-三氟甲基噻唑-5-甲酸乙酯的设计、合成与生物活性
2.Marine biological toxins——A kind of importantlead compounds for new drug research;海洋生物毒素——一类重要的新药研究先导化合物
3.A novellead compound, 4-[4-(3, 4-dimethoxyphenyl)-2-methyl-thiazole-5-carbonyl] morpholine (5), was designed and synthesized from 3, 4-dimethoxyacetophenone via six steps: esterification, chlormation, ring condensation, and hydrolysis to form the free acid, followed by formation of the acid chloride which, when reacted with morpholine, produces the desired amide (5).以3,4-二甲氧基苯乙酮为原料,经酯化、氯化、环化、水解、酰氯化和胺化六步制得新型先导化合物4-[4-(3,4-二甲氧苯基)-2-甲基噻唑-5-甲酰基]吗啉(5)。
英文短句/例句
1.Biosynthesis of Mildiomaycin Derivative and Its Analysis Identification;米多霉素类先导化合物的生物合成与分析鉴定
2.Natural products are one of the moat important sources of the lead compounds in drug discovery.天然产物是药物先导化合物的重要来源。
3.Natural products provide the most important sources of lead compounds in drug discovery.天然产物是药物发现中先导化合物的重要来源。
4.Anticardiovascular Disease Agent from Insects;从昆虫体内分离抗循环疾病药物的先导化合物
5.Synthesis and Biological Activities of Pesticide Lead Compound;亚结构连接法合成筛选农药先导化合物
6.Research and synthesis of a key intermediate of HMOA with anti-HIV activity抗艾滋病先导化合物HMOA重要中间体的合成
7.Studies on Lead Compounds of Brown Alga Leathesia Nana and Marine Sponge Tedania sp.;小粘膜藻和苔海绵活性先导化合物研究
8.Discovering hIL-6 Antagonist from Synthetic Compound Database by Using Structure-Based Virtual Screening;基于结构信息虚拟筛选hIL-6拮抗先导化合物
9.Novel Antitumor Precursor of Color Derivatives Aiming of DNA: Design, Synthesis and Evaluation Biological Activity;以DNA为靶标的色素衍生抗肿瘤先导化合物的合成和生物活性
10.Studies on Designation and Synthesis of the Leading Compound Desmosdumotin C Derivatives;活性先导化合物毛叶假鹰爪素C衍生物的设计与合成
11.The Synthesis of the Novel Imidazoles Pesticide and Their Experiments for Testing Insects;咪唑类新农药先导化合物的合成及其初步药效试验
12.Structure-based Novel Inhibitors Compounds Discovered by Rational Design and Screening Research;基于靶酶结构的新型抑制剂先导化合物的合理设计与筛选研究
13.Structure-Based Design and Synthesis of the Lead Compounds of Novel D1 Protease Inhibitors基于D1蛋白酶结构的抑制剂先导化合物的设计与合成
14.DNA Targeted Heterocycle-fused Naphthalene Derivatives: Design, Synthesis and Biological EvaluationDNA靶向萘并杂环抗肿瘤先导化合物的合成及筛选
15.Isolation and Purification of Native Spinach D1 Protease and Its Interaction with Novel Small Inhibitors;D1蛋白酶的分离纯化及其与抑制剂先导化合物的相互作用
16.Functional Analysis of Novel Antituberculosis Drug Targets TPP and LipF, and Primary Screening of Lead Compounds;新型抗结核药靶TPP和LipF的功能分析及先导化合物的初步筛选
17.Studies on the Anti-HIV Leading Compounds from Torreya Grandis cv. Merrilli and Structure Modifications;香榧中抗艾滋病病毒先导化合物的研究和结构修饰
18.Screening of Lead Compound of Algaecide for Microcystis and Analysis of Toxic Effects;微囊藻杀藻剂先导化合物的筛选及毒性效应分析
相关短句/例句
lead compounds先导化合物
1.Recent advances in the study of antifungallead compounds with new chemical scaffolds;新结构类型抗真菌先导化合物的研究进展
2.Chemical modification oflead compounds by monasacchrides and their derivatives;糖类对先导化合物的化学修饰及其在药学中的应用
3.In order to find screening rules suitable forlead compounds of pesticide,five descriptors:logarithm of partition coefficient of octanol/water(LogP),relative molar weight(MW),number of hydrogen-bond donors(NHD),number of hydrogen-bond acceptors(NHA),polar surface area(PSA)and carcinogenic and mutagenic toxicities of 242 fungicides,512 herbicides and 399 insecticides were calculated and analyzed.为了寻找适合于农药的先导筛选规则,对242个杀菌剂、512个除草剂和399个杀虫剂的5个描述符:疏水常数(LogP)、相对分子质量(MW)、氢键给体数(NHD)、氢键受体数(NHA)、分子极性表面积(PSA)和毒性进行了计算和分析,提出了杀菌剂、除草剂和杀虫剂先导化合物的筛选规则。
3)leading compound先导化合物
1.The work of isolating, purifying and identifying newleading compounds from Rhodomela confervoides and Scylosiphon lomcnkirins w.并对其中生物量较大的松节藻、萱藻进行了先导化合物的分离纯化和结构鉴定，从中分离纯化出色素、甾醇、甘油酯和溴酚类化合物30多个，并运用一维核磁共振(~1HNMR、~(13)CNMR、DEPT)、二维核磁共振(~1H-~1Hcosy、HMBC、HMQC)、红外光谱(IR)、质谱(EI/MS、FAB/MS)等现代波谱分析技术分析鉴定了化合物15个，其中15个为新化合物，1个为首次从自然界中分离得到。
4)leading compounds先导化合物
1.Methodology for quick finding ofleading compounds based on botanical metabonomic concept of determination for mixture by 1H-NMR;基于植物代谢组学混合物氢谱测定概念快速发现先导化合物的方法学研究
2.Asleading compounds these stilenes were modified by alkylation, glycosylation and association on the basis of the theory of structure modification and the theory of structure-activity relationships.合成了55种化合物,其中有16种结构简单的芪类化合物和20种修饰产物,前者经初步活性检测表明:化合物1、3、4、6具有抑制肿瘤细胞的活性;以它们为先导化合物,根据先导化合物的结构修饰和构效关系理论,进行了以下修饰。
puter-aided drug design(CADD) which playing a hinging role during new drug research and development is a multi-subject crossing subject,especially the discovery and optimization ofleading compounds.计算机辅助药物设计(CADD)是多学科交叉的边缘学科,在药物研发过程中起着枢纽作用,特别在先导化合物的发现和优化中发挥重要作用。
5)lead compounds药物先导化合物
binatorial chemistry is a new strategy for discovery and optimization oflead compounds in drug design in 1990s.组合化学是进入９０年代以来寻找及优化新药先导化合物的主要研究方法，其特点是改变了传统的逐一合成、逐一纯化、逐一筛选的模式，而是以合成和筛选化学库的形式完成寻找及优化药物先导化合物，极大地加快了药物先导化合物出现的速度。
6)pesticide guide compound农药先导化合物
1.Some compounds, which conformed to the requirements ofpesticide guide compound, were synthesized.用 QSAR理论为指导 ,对吡虫啉农药分子进行结构改造 ,合成出数种达到农药先导化合物要求的化合物 ,具有进一步优化结构从而成为新农药的良好潜
延伸阅读
先导化合物分子式：CAS号：性质：能够进行各种结构修饰的母体化合物或活性分子设计最初产生的结构图像。这种母体化合物或图像能进行结构修饰，并衍生出一系列新化合物，借以发现高活性分子结构。
